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KMID : 0361720130240040237
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Korean Journal of perinatology
2013 Volume.24 No. 4 p.237 ~ p.243
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Effect of Indomethacin Treatment in Full-term Infants with Symptomatic Patent Ductus Arteriosus
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Kim Han-Kyul
Choi In-Su
Cho Hwa-Jin
Song Eun-Song
Cho Young-Kuk
Choi Young-Youn
Ma Jae-Sook
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Abstract
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Purpose: Indomethacin has been reported as the prophylaxis and initial treatment of preterm infants with patentductus arteriosus (PDA). However, there was controversy over indomethacin treatment in full-term infants with symptomatic PDA. Therefore, we evaluate the effect of indomethacin as a treatment of full-term infants withsymptomatic PDA.
Methods: A retrospective study was performed to evaluate the effectiveness of indomethacin in full-terminfants who had birth weight ≥2,500 g and a gestational age ≥37 weeks with symptomatic PDA at ChonnamNational University Hospital between January 2007 and December 2009. According to responsiveness ofindomethacin, we classified them into three groups: 1) complete responder which were completely closed after indomethacin treatment, 2) partial responder which were incompletely closed but symptoms were improved, 3)non responder which were conducted surgical ligation because did not respond.
Results: Among the total 29 full-term infants treated with indomethacin, 13 (44.8%) were complete responder,8 (27.6%) were partial responder, and 8 (27.6%) were non responder. There were no significant differences inbirth weight, narrow diameter of PDA, and dose of indomethacin between three groups. However, the age atinitiation of treatment using indomethacin of complete (4.8±4.5 days, P =0.03) and partial responder (6.3±2.0days, P =0.04) were earlier than those of non responder (13.8±8.1 days).
Conclusion: Indomethacin can expect an effective treatment of PDA in full-term infants prior to surgical ligation.
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KEYWORD
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Indomethacin, Patent ductus arteriosus, Full-term infants
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